Understanding how certain gut bacteria can reduce inflammation in the intestines
Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestine
This study is looking at how certain good bacteria in your gut can help manage inflammatory bowel disease (IBD) by promoting healing and reducing inflammation, with the goal of creating new probiotic treatments that work better for people like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11004276 on NIH RePORTER |
What this research studies
This research investigates the role of specific gut bacteria in managing inflammatory bowel disease (IBD), which affects many adults. It aims to develop new treatment strategies that use beneficial microbes to restore balance in the gut and reduce inflammation, rather than just blocking harmful immune responses. By exploring how these microbes can survive in an inflamed intestine and promote healing, the study seeks to create 'designer probiotics' that could offer better outcomes for patients. The research involves analyzing the interactions between these bacteria and the immune system to identify effective therapeutic approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults suffering from inflammatory bowel disease, particularly those who have not responded well to existing treatments.
Not a fit: Patients with inflammatory bowel disease who are currently well-managed on existing therapies may not see additional benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for inflammatory bowel disease, improving the quality of life for patients.
How similar studies have performed: While there have been limited successes with probiotic treatments in the past, this approach of creating designer probiotics is relatively novel and untested.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Ahern, Philip Patrick — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Ahern, Philip Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.