Understanding how certain gut bacteria can control C. difficile infections
Commensal control of C. difficile virulence
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11007225
This study is looking at how good bacteria in our gut can help protect against Clostridioides difficile infections, which can cause serious stomach problems, and it's for anyone interested in understanding how these bacteria work and how they might lead to better treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11007225 on ClinicalTrials.gov |
What this research studies
This research investigates the role of beneficial gut bacteria in protecting against Clostridioides difficile infections, which can lead to severe gastrointestinal issues. The team has identified specific bacterial species that help prevent these infections and others that may worsen them. By studying these interactions in mice with different microbiota, the researchers aim to uncover the mechanisms behind this protection and develop new treatments and biomarkers for predicting successful therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for C. difficile infections, particularly those with a history of antibiotic use or gastrointestinal disorders.
Not a fit: Patients who are not at risk for C. difficile infections or those who do not have a significant history of gastrointestinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively prevent or treat C. difficile infections, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using gut microbiota to manage infections, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRY, LYNN — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: BRY, LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.