Understanding how certain genetic instructions affect brain development
Functional long noncoding RNAs in neural development
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11124125
This project looks at how special genetic instructions called long noncoding RNAs help shape the brain, especially in conditions like Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11124125 on ClinicalTrials.gov |
What this research studies
Our brains rely on many genetic instructions, including long noncoding RNAs (lncRNAs), which play a role in how our brains develop and function. When these lncRNAs don't work correctly, they can contribute to neurological conditions like Alzheimer's disease. This work aims to uncover the specific jobs of these lncRNAs and how they influence the growth of brain cells. By understanding these basic mechanisms, we hope to learn more about how brain development goes awry in disease.
Who could benefit from this research
Good fit: This is basic science research, so there are no direct patient participation opportunities at this stage.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this early-stage research.
Why it matters
Potential benefit: This foundational work could lead to new ways to understand and potentially treat neurological disorders, including Alzheimer's disease, by targeting these specific genetic instructions.
How similar studies have performed: While the broad concept of lncRNAs is known, the specific functions and mechanisms of many brain-specific lncRNAs, like Pnky, are still being discovered.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIM, DANIEL A — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: LIM, DANIEL A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease