Understanding how certain genetic elements move and splice in human DNA
Structural Biology of Retrotransposition and pre-mRNA Splicing
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11052582
This study is looking at how certain genetic pieces called group II introns move around in our DNA and help with the process of making proteins, which is important for our health, and it hopes to find new ways to help people with genetic disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11052582 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which specific genetic elements, known as group II introns, move within the human genome and how they contribute to the process of pre-mRNA splicing. By utilizing advanced techniques like cryo-electron microscopy, the study aims to uncover the molecular details of retrotransposition and splicing, which are crucial for gene expression. Patients may benefit from insights gained about genetic disorders linked to these processes, potentially leading to new therapeutic strategies. The research focuses on the biochemical interactions and structural biology of these elements to better understand their roles in human health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic disorders related to splicing or retrotransposition.
Not a fit: Patients with conditions unrelated to genetic splicing or retrotransposition may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for genetic diseases by enhancing our understanding of gene regulation and expression.
How similar studies have performed: Previous research has shown promising results in understanding genetic elements and their roles in diseases, indicating that this approach has potential for significant discoveries.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TOOR, NAVTEJ SINGH — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: TOOR, NAVTEJ SINGH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.