Understanding how certain genetic elements interact with DNA replication in cells
The cross-regulation of host DNA replication and LTR Retrotransposons
['FUNDING_OTHER'] · RUTGERS, THE STATE UNIV OF N.J. · NIH-10621925
This study looks at how certain genetic elements, called retrotransposons, interact with the DNA copying process in fission yeast, helping us understand how they can affect our genes and how our bodies protect against their potential harm, which could also shed light on diseases like cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS, THE STATE UNIV OF N.J. (nih funded) |
| Locations | 1 site (PISCATAWAY, UNITED STATES) |
| Trial ID | NIH-10621925 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between host DNA replication processes and LTR retrotransposons, which are genetic elements that can multiply and insert themselves into new locations in the genome. By studying these interactions in fission yeast, the research aims to uncover how retrotransposons influence genome structure and regulation, as well as the defense mechanisms that eukaryotes have developed to suppress their potentially harmful effects. The methodology includes examining RNA interference pathways and their role in protecting genetic material during reproduction. This work could provide insights into fundamental biological processes that may have implications for understanding various diseases, including cancers.
Who could benefit from this research
Good fit: Ideal candidates for potential benefit from this research include individuals with genetic disorders or cancers that may be influenced by retrotransposon activity.
Not a fit: Patients with conditions unrelated to genetic regulation or those not affected by transposable elements may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing genetic disorders and cancers by enhancing our understanding of genome regulation.
How similar studies have performed: Previous research has shown success in understanding host-transposon interactions, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
PISCATAWAY, UNITED STATES
- RUTGERS, THE STATE UNIV OF N.J. — PISCATAWAY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZARATIEGUI BIURRUN, MIGUEL ANGEL — RUTGERS, THE STATE UNIV OF N.J.
- Study coordinator: ZARATIEGUI BIURRUN, MIGUEL ANGEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer