Understanding how certain genetic elements are controlled in yeast
Official title: Evolution of Retrotransposon Control Mechanisms
Funded at University of Georgia · NIH-11020066 · Data updated 2026-11-12
This study is looking at how certain genetic elements that can move around in our DNA might cause problems, using yeast to learn more about how they work and how we might control them, which could help us understand diseases in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $372,263 |
| NIH project number | 1R01GM156837-01 |
| Project ID | NIH-11020066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions that may be influenced by retrotransposon activity or DNA instability.
✕Less likely to help
Patients with conditions unrelated to genetic instability or retrotransposon activity may not benefit from this research.
What this research studies
This research investigates the mechanisms that regulate retrotransposons, which are genetic elements that can move within the genome and potentially cause genetic instability. By using the yeast model organism, researchers aim to uncover new forms of control over these elements, which could have implications for understanding human diseases linked to genetic instability. The study will explore how these elements interact and evolve, providing insights into their roles in cellular processes and development.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing genetic disorders related to DNA damage and instability.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown that understanding genetic element regulation can lead to significant advancements in genetic medicine.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Garfinkel, David J. — University of Georgia
- Study coordinator: Garfinkel, David J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.