Understanding how certain genetic elements are controlled in yeast
Evolution of Retrotransposon Control Mechanisms
This study is looking at how certain genetic elements that can move around in our DNA might cause problems, using yeast to learn more about how they work and how we might control them, which could help us understand diseases in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-11020066 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate retrotransposons, which are genetic elements that can move within the genome and potentially cause genetic instability. By using the yeast model organism, researchers aim to uncover new forms of control over these elements, which could have implications for understanding human diseases linked to genetic instability. The study will explore how these elements interact and evolve, providing insights into their roles in cellular processes and development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions that may be influenced by retrotransposon activity or DNA instability.
Not a fit: Patients with conditions unrelated to genetic instability or retrotransposon activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing genetic disorders related to DNA damage and instability.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown that understanding genetic element regulation can lead to significant advancements in genetic medicine.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Garfinkel, David J. — University of Georgia
- Study coordinator: Garfinkel, David J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.