Understanding how certain genetic elements affect mRNA stability and protein production
Official title: Regulation of upstream open reading frames in mRNA stability and translation
Funded at Michigan State University · NIH-11129778 · Data updated 2026-11-12
This study is looking at tiny parts of genes that help control how our genes work, which is important for understanding diseases, and it uses a plant called Arabidopsis to find out how these parts affect the way proteins are made, with the hope that this could lead to better treatments for people with gene-related health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | July 2, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $366,684 |
| NIH project number | 5R35GM155375-02 |
| Project ID | NIH-11129778 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases linked to abnormal gene expression.
✕Less likely to help
Patients with conditions unrelated to gene regulation or mRNA stability may not receive any benefit from this research.
What this research studies
This research investigates the role of upstream open reading frames (uORFs) in regulating gene expression, which is crucial for understanding various human diseases. By utilizing high-throughput sequencing and advanced bioinformatics, the study aims to identify and characterize the features and regulatory mechanisms of uORFs using the model organism Arabidopsis. The research will explore how these genetic elements influence mRNA stability and the translation of proteins, potentially uncovering new insights into gene regulation. Patients may benefit from the findings as they could lead to better understanding and treatment of diseases linked to gene expression abnormalities.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of gene regulation, leading to improved treatments for diseases associated with mRNA stability and translation issues.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation through similar approaches, indicating potential for significant advancements in this area.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Hsu, Polly — Michigan State University
- Study coordinator: Hsu, Polly
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.