Understanding how certain genetic changes lead to aggressive prostate cancer
Microenvironmental drivers of indolent to aggressive prostate cancer switch mediated by combined MYC Activation and PTEN loss
This study is looking at how certain genetic changes in prostate cancer can make it more aggressive, and it's for anyone interested in understanding how these changes affect the immune system and could lead to better treatments for prostate cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10918243 on NIH RePORTER |
What this research studies
This research investigates the transition from indolent to aggressive prostate cancer by examining the roles of specific genetic changes, particularly the loss of the PTEN gene and the activation of the MYC gene. Using advanced mouse models, the study aims to uncover how these genetic alterations influence the tumor microenvironment, particularly through immune evasion mechanisms. By analyzing the interactions between cancer cells and surrounding immune cells, the research seeks to identify potential biomarkers and therapeutic targets for better management of prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with prostate cancer, particularly those with low-grade lesions that may harbor aggressive characteristics.
Not a fit: Patients with non-prostate cancers or those with advanced metastatic prostate cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for identifying and treating aggressive prostate cancer, potentially saving lives.
How similar studies have performed: Previous research has shown promising results in understanding the genetic drivers of cancer progression, suggesting that this approach may yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Yegnasubramanian, Srinivasan — Johns Hopkins University
- Study coordinator: Yegnasubramanian, Srinivasan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.