Understanding how certain genes work together to prevent diseases like cancer.
Official title: Coregulation of genes by pioneer transcription factors and noncoding RNAs
Funded at Brown University · NIH-11084719 · Data updated 2026-11-12
This study is exploring how certain molecules in our DNA work together to control gene activity, which is important for healthy development and preventing diseases like cancer and neurodegeneration, and it aims to find new ways to fix gene problems that can lead to these illnesses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | May 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $32,272 |
| NIH project number | 3R35GM153389-01S1 |
| Project ID | NIH-11084719 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by cancers or neurodegenerative diseases linked to gene expression issues.
✕Less likely to help
Patients with conditions unrelated to gene regulation or those not affected by cancer or neurodegeneration may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the co-regulation of genes, which is crucial for proper development and disease prevention. By focusing on how DNA-binding transcription factors and long non-coding RNAs interact, the project aims to uncover the rules that dictate when and where specific genes are activated. This understanding could lead to new strategies for correcting gene expression errors that contribute to diseases such as cancer and neurodegeneration. The research employs advanced techniques to analyze gene interactions in a three-dimensional context.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that correct misregulated gene expression in various diseases.
How similar studies have gone: Other research has shown promise in understanding gene regulation mechanisms, suggesting that this approach could yield significant insights.
Where this research is happening
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Brown University
Providence, United States Active
Researchers
- Principal investigator: Larschan, Erica Nicole — Brown University
- Study coordinator: Larschan, Erica Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.