Understanding how certain genes help the immune system fight viral infections
Official title: Retroviral infection and new modulators of the MHCII pathway
Funded at University of Chicago · NIH-11113876 · Data updated 2026-11-12
This study is looking at how certain genes help our immune system make antibodies that fight off long-lasting viral infections, like hepatitis B and C, and it aims to find ways to improve treatments for people dealing with these viruses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | June 12, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $793,725 |
| NIH project number | 5R01AI175279-02 |
| Project ID | NIH-11113876 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with chronic viral infections such as hepatitis B or C, particularly those who exhibit varying immune responses.
✕Less likely to help
Patients with acute viral infections or those without a history of viral infections may not receive direct benefits from this research.
What this research studies
This research investigates how specific genes influence the immune system's ability to produce neutralizing antibodies against persistent viral infections. By studying both mice and humans, the researchers aim to uncover the mechanisms that enable some individuals to effectively control viruses like hepatitis B and C. The study employs advanced genetic analysis and bioinformatics to identify variations in genes that may affect immune responses. Patients may benefit from insights that could lead to improved treatments for viral infections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the immune response against viral infections in patients.
How similar studies have gone: Previous research has shown success in understanding immune responses to viral infections, making this approach promising yet still exploring novel genetic factors.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Golovkina, Tatyana V — University of Chicago
- Study coordinator: Golovkina, Tatyana V
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.