Understanding how certain genes help repair DNA damage
BRCA-dependent Mechanisms of Genome Maintenance and Repair
This study is looking at how certain genes, like BRCA1 and BRCA2, help fix broken DNA, which is really important for keeping our cells healthy, and it hopes to explain why changes in these genes can lead to cancer, helping to find better treatments in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10909086 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which specific genes, particularly BRCA1 and BRCA2, contribute to the repair of DNA double-strand breaks, which are critical for maintaining genomic stability. The approach combines biochemical experiments, structural biology, and cell-based studies to explore how these genes function in homologous recombination, a key DNA repair process. By understanding these mechanisms, the research aims to clarify why mutations in these genes can lead to cancer and other genetic disorders, potentially guiding future therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with known BRCA1 or BRCA2 mutations or those with a family history of breast or ovarian cancer.
Not a fit: Patients without BRCA mutations or those not at risk for hereditary breast and ovarian cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cancer risk in individuals with BRCA mutations and inform targeted therapies.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms related to BRCA genes, indicating that this approach is built on a foundation of successful studies.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Kwon, Youngho — University of Texas Hlth Science Center
- Study coordinator: Kwon, Youngho
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.