Understanding how certain genes help organisms survive starvation
Genetic and Genomic Analysis of Starvation Resistance in C. elegans
This study looks at how tiny roundworms can survive without food and hopes to find out if the same genes that help them might also help us understand diseases like cancer and diabetes, which could lead to new treatments for people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10912748 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular mechanisms that allow the roundworm C. elegans to resist starvation. By studying specific genes known to influence starvation resistance, the research aims to uncover how these genes might relate to human diseases such as cancer and diabetes. The approach involves detailed genetic analysis and experimentation to identify how these genes function and interact under conditions of nutrient deprivation. Insights gained from this research could provide valuable information on how similar pathways operate in humans, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with metabolic disorders, cancer, or age-related diseases.
Not a fit: Patients with conditions unrelated to metabolic regulation or starvation resistance may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating diseases related to metabolism and aging, improving patient outcomes.
How similar studies have performed: Other research has shown success in using model organisms like C. elegans to uncover fundamental biological processes that have implications for human health.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Baugh, Larry Ryan — Duke University
- Study coordinator: Baugh, Larry Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.