Understanding how certain genes help fight viral infections
Next Generation Resolution of Antiviral Gene Networks
This study is looking at how certain genes help our cells fight off viruses, like COVID-19, by using special samples from people with specific genetic conditions, so we can better understand how our immune system works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10898902 on NIH RePORTER |
What this research studies
This research investigates the role of type I interferons and their associated genes in establishing an antiviral state in cells during viral infections. By analyzing unique samples from individuals with specific hereditary conditions, the study aims to identify key interferon-stimulated genes (ISGs) that provide resistance against various viruses. Utilizing advanced single-cell RNA sequencing technology, the researchers will explore how these genes work together and how their expression is regulated in different cell types. This approach could lead to a deeper understanding of the immune response to viruses like COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with hereditary syndromes affecting interferon responses or those who have experienced severe viral infections.
Not a fit: Patients with viral infections that do not involve type I interferon responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new antiviral therapies that enhance the body's natural defenses against a wide range of viral infections.
How similar studies have performed: Previous research has shown promise in understanding the role of interferons in viral resistance, making this approach a continuation of established findings.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Rosenberg, Brad — Icahn School of Medicine at Mount Sinai
- Study coordinator: Rosenberg, Brad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.