Understanding how certain genes control von Willebrand factor levels in the blood
Official title: Investigation of factors regulating von Willebrand factor expression
Funded at Washington University · NIH-11016812 · Data updated 2026-11-12
This study is looking at how our genes influence the levels of a protein called von Willebrand factor, which is important for blood clotting, to help us understand bleeding and clotting disorders better and improve future treatments for people with these conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 15, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $337,603 |
| NIH project number | 1P01HL173579-01A1 |
| Project ID | NIH-11016812 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with bleeding disorders or those experiencing abnormal blood clotting.
✕Less likely to help
Patients without any bleeding or clotting disorders may not benefit from this research.
What this research studies
This research aims to explore the genetic factors that regulate the expression of von Willebrand factor (VWF), a protein crucial for blood clotting. By examining various cell types and using advanced techniques like single-cell analysis and spatial transcriptomics, the study will identify how VWF levels are controlled in both healthy individuals and those with bleeding or clotting disorders. The findings could lead to a better understanding of the mechanisms behind these conditions and inform future treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bleeding and thrombotic disorders by providing insights into the regulation of VWF levels.
How similar studies have gone: Previous research has shown promise in understanding gene regulation related to blood coagulation, suggesting that this approach could yield valuable insights.
Where this research is happening
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Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Lillicrap, David P — Washington University
- Study coordinator: Lillicrap, David P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.