Understanding how certain genes control the development of reproductive cells.
Establishment of the meiotic cell cycle program through post-transcriptional regulation by MEIOC and YTHDC2
This study is looking at how two genes, MEIOC and YTHDC2, help control the process of making sperm and eggs, which is important for fertility, and it aims to find ways to improve fertility and understand some birth defects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10903959 on NIH RePORTER |
What this research studies
This research investigates the role of two specific genes, MEIOC and YTHDC2, in the process of meiosis, which is essential for the formation of sperm and eggs. It focuses on how these genes help regulate the cell cycle during the early stages of germ cell development, ensuring that cells properly undergo division and genetic recombination. By studying the interactions between these genes and their effects on cell cycle regulators, the research aims to uncover mechanisms that could lead to improved fertility outcomes and better understanding of certain birth defects.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing infertility or those with a family history of genetic disorders related to chromosomal abnormalities.
Not a fit: Patients who are not experiencing fertility issues or do not have a history of genetic abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing infertility and reducing the risk of genetic abnormalities in offspring.
How similar studies have performed: Other research has shown promising results in understanding gene regulation during meiosis, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Mikedis, Maria — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Mikedis, Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.