Understanding how certain genes control glioblastoma tumors
Official title: Identifying and Targeting 3D Regulatory Nodes that Maintain Glioblastoma Programs
Funded at Weill Medical Coll of Cornell Univ · NIH-11076817 · Data updated 2026-11-12
This study is looking at how certain genes and their activity affect glioblastoma, a tough type of brain tumor, to find new ways to help treat it better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $675,615 |
| NIH project number | 5R01NS136475-02 |
| Project ID | NIH-11076817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with glioblastoma, particularly those with IDH-wildtype tumors.
✕Less likely to help
Patients with other types of brain tumors or those who do not have glioblastoma may not benefit from this research.
What this research studies
This research investigates the complex genetic and epigenetic factors that contribute to glioblastoma, a highly aggressive brain tumor. By analyzing the three-dimensional interactions of enhancers and promoters in glioma stem-like cells, the study aims to identify key regulatory modules that maintain the tumor's growth and adaptability. The approach involves constructing detailed interaction networks to uncover how these genetic elements influence tumor behavior and treatment resistance. Patients may benefit from insights that could lead to more effective therapies targeting these regulatory mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that specifically target the genetic drivers of glioblastoma, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promise in targeting genetic and epigenetic factors in cancer treatment, suggesting that this approach could yield significant advancements.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Apostolou, Effie — Weill Medical Coll of Cornell Univ
- Study coordinator: Apostolou, Effie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.