Understanding how certain genes contribute to lung cancer
Genomic Instability in Lung Cancer: Unraveling the Impact of the APOBEC3 Family
['FUNDING_FELLOWSHIP'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11070558
This study is looking at how certain genes might cause changes in lung cancer cells in people who don’t smoke, with the hope of finding better treatments and ways to predict how the cancer will behave.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11070558 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the APOBEC3 family of genes in causing mutations in lung cancer cells, particularly in nonsmoking patients. By using advanced techniques like whole genome sequencing, the study aims to identify which specific APOBEC3 genes are responsible for these mutations and how they contribute to cancer progression and treatment resistance. Patients may benefit from insights gained that could lead to improved therapies and prognostic tools for lung cancer. The research will involve analyzing cancer cell lines to better understand the mechanisms behind these mutations.
Who could benefit from this research
Good fit: Ideal candidates for this research are nonsmoking lung cancer patients, particularly those with specific genetic profiles related to the APOBEC3 family.
Not a fit: Patients with lung cancer who are smokers or those whose cancer is not influenced by the APOBEC3 family may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and better prognostic assessments for lung cancer patients.
How similar studies have performed: Previous research has shown that understanding genetic mutations in cancer can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STRIEPEN, JOSEFINE — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: STRIEPEN, JOSEFINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, Breast Cancer Cell, Cancer Biology, Cancer Cause