Understanding how certain genes contribute to lung cancer
Official title: Genomic Instability in Lung Cancer: Unraveling the Impact of the APOBEC3 Family
Funded at Weill Medical Coll of Cornell Univ · NIH-11070558 · Data updated 2026-11-12
This study is looking at how certain genes might cause changes in lung cancer cells in people who don’t smoke, with the hope of finding better treatments and ways to predict how the cancer will behave.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 7, 2025 |
| Project end | April 6, 2027 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 1F31CA290850-01A1 |
| Project ID | NIH-11070558 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are nonsmoking lung cancer patients, particularly those with specific genetic profiles related to the APOBEC3 family.
✕Less likely to help
Patients with lung cancer who are smokers or those whose cancer is not influenced by the APOBEC3 family may not benefit from this research.
What this research studies
This research investigates the role of the APOBEC3 family of genes in causing mutations in lung cancer cells, particularly in nonsmoking patients. By using advanced techniques like whole genome sequencing, the study aims to identify which specific APOBEC3 genes are responsible for these mutations and how they contribute to cancer progression and treatment resistance. Patients may benefit from insights gained that could lead to improved therapies and prognostic tools for lung cancer. The research will involve analyzing cancer cell lines to better understand the mechanisms behind these mutations.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and better prognostic assessments for lung cancer patients.
How similar studies have gone: Previous research has shown that understanding genetic mutations in cancer can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Striepen, Josefine — Weill Medical Coll of Cornell Univ
- Study coordinator: Striepen, Josefine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.