Understanding how certain genes contribute to insulin resistance and diabetes.
Official title: Molecular Mechanisms of Insulin Resistance Associated Loci
Funded at Stanford University · NIH-11064064 · Data updated 2026-11-12
This study is looking at how certain genes might cause insulin resistance, which can lead to type 2 diabetes and heart problems, and it hopes to find new ways to help people manage these conditions better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $563,200 |
| NIH project number | 5R01DK137889-02 |
| Project ID | NIH-11064064 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for type 2 diabetes or those with insulin resistance.
✕Less likely to help
Patients who do not have insulin resistance or type 2 diabetes may not benefit from this research.
What this research studies
This research investigates the genetic factors that lead to insulin resistance, a key contributor to type 2 diabetes and cardiovascular diseases. By analyzing data from various studies, the team aims to identify specific genes that play a role in insulin resistance, particularly focusing on adipose tissue. The research employs advanced techniques like single-cell analysis and CRISPR gene editing to explore how these genes function and interact within the body. Patients may benefit from new therapeutic targets that could emerge from this work.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for insulin resistance and type 2 diabetes, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to insulin resistance, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Knowles, Joshua Wiley — Stanford University
- Study coordinator: Knowles, Joshua Wiley
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.