Understanding how certain genes can help suppress small cell lung cancer
Official title: Interrogating a novel axis of tumor suppression in small cell lung cancer
Funded at Fred Hutchinson Cancer Center · NIH-11073535 · Data updated 2026-11-12
This study is looking at how certain genes can help stop the growth of small cell lung cancer, which is a tough type of cancer to treat, and aims to find new ways to help patients by exploring a specific pathway that shows promise in fighting this disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $548,915 |
| NIH project number | 1R01CA287476-01A1 |
| Project ID | NIH-11073535 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with small cell lung cancer, particularly those with early-stage disease.
✕Less likely to help
Patients with other types of lung cancer or those who are not diagnosed with small cell lung cancer may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to tumor suppression in small cell lung cancer (SCLC), a highly aggressive cancer with limited treatment options. By using genetically engineered mouse models and advanced cellular techniques, the team aims to identify key pathways that can inhibit tumor growth. The study focuses on a specific stress-activated protein kinase pathway that has shown promise in preliminary findings. Ultimately, the goal is to uncover new therapeutic targets that could lead to effective treatments for SCLC patients.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for small cell lung cancer, improving treatment outcomes for patients.
How similar studies have gone: Other research has shown success in targeting genetic pathways in various cancers, suggesting that this approach may yield valuable insights for small cell lung cancer as well.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Macpherson, David — Fred Hutchinson Cancer Center
- Study coordinator: Macpherson, David
Related research
Other NIH-funded projects on the same topics.
-
ABL kinase signaling and DNA collisions in small cell lung cancer
A drug target study in small cell lung cancer explores how blocking ABL kinase affects conflicts between transcription and DNA replication, which could influence tumor growth and survival.
-
XRN1 as a potential therapy target in lung cancer
A scientist-led program will study a cellular gene called XRN1 to see if turning it off can help treat non-small cell lung cancer.
-
Intermittent fasting with PD-1 inhibitors for non-small cell lung cancer
This grant tests whether a fasting-mimicking diet can boost the effectiveness of PD-1 inhibitors for people with non-small cell lung cancer.
-
Targeting STRAP to curb NSCLC spread with nanoparticle therapy
Aimed at non-small cell lung cancer, this grant tests how blocking a protein called STRAP with nanoparticles could slow cancer spread and make chemotherapy work better.
-
Modeling tumor differences to guide new treatments for resistant small cell lung cancer
A study aims to understand why some small cell lung cancer tumors resist treatment and use those insights to develop new targeted therapies.
-
TP53-mutant NSCLC: how epigenetic viral mimicry could boost immune therapy
A research grant exploring how p53 mutations in non-small cell lung cancer affect responses to a viral mimicry-based epigenetic therapy, with the goal of improving immune therapy outcomes for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.