Understanding how certain genes can help suppress small cell lung cancer
Interrogating a novel axis of tumor suppression in small cell lung cancer
This study is looking at how certain genes can help stop the growth of small cell lung cancer, which is a tough type of cancer to treat, and aims to find new ways to help patients by exploring a specific pathway that shows promise in fighting this disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11073535 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to tumor suppression in small cell lung cancer (SCLC), a highly aggressive cancer with limited treatment options. By using genetically engineered mouse models and advanced cellular techniques, the team aims to identify key pathways that can inhibit tumor growth. The study focuses on a specific stress-activated protein kinase pathway that has shown promise in preliminary findings. Ultimately, the goal is to uncover new therapeutic targets that could lead to effective treatments for SCLC patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with small cell lung cancer, particularly those with early-stage disease.
Not a fit: Patients with other types of lung cancer or those who are not diagnosed with small cell lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for small cell lung cancer, improving treatment outcomes for patients.
How similar studies have performed: Other research has shown success in targeting genetic pathways in various cancers, suggesting that this approach may yield valuable insights for small cell lung cancer as well.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Macpherson, David — Fred Hutchinson Cancer Center
- Study coordinator: Macpherson, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.