Understanding how certain genes are expressed from only one parent in the immune system
Monoallelically expressed genes as a novel mechanism of genetic errors of immunity
['FUNDING_P01'] · WASHINGTON UNIVERSITY · NIH-11010137
This study is looking at how some genes only work from one parent instead of both, and how this might affect your immune system and the way certain diseases show up in different people, so you can better understand how your genes might influence your health.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11010137 on ClinicalTrials.gov |
What this research studies
This research investigates a unique genetic phenomenon where some genes are expressed from only one inherited allele, rather than both. It aims to explore how this monoallelic expression affects immune function and contributes to genetic diseases. By analyzing the mechanisms behind this process, the study seeks to uncover how it influences variability in disease symptoms among individuals. Patients may benefit from insights into how their genetic makeup affects their immune responses and disease outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have genetic immune disorders or related conditions.
Not a fit: Patients with immune disorders not linked to genetic factors or those over the age of 11 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of genetic diseases related to immune function.
How similar studies have performed: While the concept of monoallelic expression is gaining attention, this specific approach is relatively novel and has not been extensively tested in the context of immune disorders.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOGUNOVIC, DUSAN — WASHINGTON UNIVERSITY
- Study coordinator: BOGUNOVIC, DUSAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.