Understanding how certain genes are expressed from only one parent in the immune system
Official title: Monoallelically expressed genes as a novel mechanism of genetic errors of immunity
Funded at Washington University · NIH-11010137 · Data updated 2026-11-12
This study is looking at how some genes only work from one parent instead of both, and how this might affect your immune system and the way certain diseases show up in different people, so you can better understand how your genes might influence your health.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 8, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $413,985 |
| NIH project number | 1P01AI186771-01 |
| Project ID | NIH-11010137 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who have genetic immune disorders or related conditions.
✕Less likely to help
Patients with immune disorders not linked to genetic factors or those over the age of 11 may not benefit from this research.
What this research studies
This research investigates a unique genetic phenomenon where some genes are expressed from only one inherited allele, rather than both. It aims to explore how this monoallelic expression affects immune function and contributes to genetic diseases. By analyzing the mechanisms behind this process, the study seeks to uncover how it influences variability in disease symptoms among individuals. Patients may benefit from insights into how their genetic makeup affects their immune responses and disease outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of genetic diseases related to immune function.
How similar studies have gone: While the concept of monoallelic expression is gaining attention, this specific approach is relatively novel and has not been extensively tested in the context of immune disorders.
Where this research is happening
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Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Bogunovic, Dusan — Washington University
- Study coordinator: Bogunovic, Dusan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.