Understanding how certain genes are expressed differently based on parental origin
Investigating molecular mechanisms and cellular functions of genomic imprinting
['FUNDING_OTHER'] · HARVARD UNIVERSITY · NIH-10890076
This study is looking at how certain genes from our parents work differently, especially in brain development, to help us understand conditions like Angelman syndrome better and find new ways to treat them.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD UNIVERSITY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-10890076 on ClinicalTrials.gov |
What this research studies
This research investigates genomic imprinting, a process where genes inherited from one parent are expressed while those from the other are silenced. The focus is on understanding the molecular mechanisms that regulate this selective gene expression and the cellular functions of these imprinted genes, particularly in the context of neurodevelopmental disorders like Angelman syndrome. By studying neuron differentiation, the researchers aim to uncover how the 3D structure of chromosomes affects gene expression and how disruptions can lead to disease. The findings could lead to improved treatments for conditions linked to genomic imprinting.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with imprinted disorders, particularly those affected by Angelman syndrome or similar conditions.
Not a fit: Patients without any genetic disorders or those not affected by imprinted gene dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better therapeutic strategies for patients with imprinted disorders, enhancing their quality of life.
How similar studies have performed: Previous research has shown success in understanding genomic imprinting and its implications for disorders like Angelman syndrome, indicating a promising avenue for further exploration.
Where this research is happening
CAMBRIDGE, UNITED STATES
- HARVARD UNIVERSITY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WHIPPLE, AMANDA JOY — HARVARD UNIVERSITY
- Study coordinator: WHIPPLE, AMANDA JOY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Angelman Syndrome