Understanding how certain genes affect tube formation in fruit flies
Official title: Acquisition of a Drosophila chamber for culturing Drosophila strains
Funded at Oakland University · NIH-10580919 · Data updated 2026-11-12
This study is looking at how certain genes in fruit flies help develop important tube-like structures in the body, which could help us understand similar processes in humans and diseases like polycystic kidney disease.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oakland University NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $18,985 |
| NIH project number | 3R15GM140376-01A1S1 |
| Project ID | NIH-10580919 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with conditions related to tubular organ malformations, such as polycystic kidney disease, may benefit from the insights gained from this research.
✕Less likely to help
Patients with unrelated conditions or those not affected by tubular organ malformations are unlikely to benefit directly from this research.
What this research studies
This research focuses on the role of the Osiris gene family in the maturation of tubular structures in Drosophila, a type of fruit fly. By using a specialized chamber to culture these flies, researchers aim to uncover fundamental mechanisms that govern the formation of tubular organs, which are crucial for various bodily functions. The study will investigate how these genes influence the trafficking of proteins necessary for proper tube development, potentially shedding light on similar processes in humans. The findings could provide insights into diseases caused by malformations in tubular structures, such as polycystic kidney disease.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of diseases related to tubular organ malformations in humans.
How similar studies have gone: Previous studies have shown success in using Drosophila to understand genetic influences on organ development, indicating that this approach is promising.
Where this research is happening
-
Oakland University
Rochester, United States Active
Researchers
- Principal investigator: Jiang, Lan — Oakland University
- Study coordinator: Jiang, Lan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.