Understanding how certain genes affect the development of facial structures and related disorders
Mechanisms of Neural Crest Induction and Craniofacial Disorders
['FUNDING_R01'] · UNIVERSITY OF DELAWARE · NIH-10824282
This study is looking at how a gene called DDX3 affects the development of important cells that help form the face and head, and it aims to understand how changes in this gene might lead to common birth defects, which could help patients with craniofacial disorders in the future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF DELAWARE (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-10824282 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific gene, DDX3, in the development of neural crest cells, which are crucial for forming various structures in the face and head. By using a model organism, Xenopus tropicalis, the researchers will explore how mutations in DDX3 can lead to common birth defects, particularly those affecting craniofacial structures. The study aims to uncover the mechanisms by which DDX3 influences cell signaling pathways that are essential for normal development. Patients may benefit from insights gained about the genetic causes of craniofacial disorders and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with craniofacial abnormalities or those with a family history of neurocristopathies.
Not a fit: Patients with craniofacial disorders not linked to genetic mutations or those unrelated to neural crest development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with craniofacial disorders caused by genetic mutations.
How similar studies have performed: Previous research has shown success in understanding genetic influences on craniofacial development, making this approach promising yet still exploring novel aspects.
Where this research is happening
Newark, UNITED STATES
- UNIVERSITY OF DELAWARE — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEI, SHUO — UNIVERSITY OF DELAWARE
- Study coordinator: WEI, SHUO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.