Understanding how certain genes affect ovarian aging and fertility
The Regulation of Ovarian Aging by H19 and let-7
['FUNDING_R01'] · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · NIH-10653125
This study is looking at how certain tiny molecules in our bodies, called noncoding RNAs, affect the aging of ovaries and fertility in women, with the goal of understanding how they influence the number and health of eggs, which are important for getting pregnant.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VERMONT & ST AGRIC COLLEGE (nih funded) |
| Locations | 1 site (BURLINGTON, UNITED STATES) |
| Trial ID | NIH-10653125 on ClinicalTrials.gov |
What this research studies
This research investigates the role of noncoding RNAs, specifically H19 and let-7, in regulating ovarian aging and its impact on fertility. The study aims to uncover how these molecules influence the quantity and quality of ovarian follicles and oocytes, which are crucial for successful pregnancies. By exploring the mechanisms behind ovarian reserve depletion and DNA damage accumulation in oocytes, the research seeks to provide insights that could improve reproductive health outcomes for women. The approach includes analyzing gene expression and follicular health in relation to maternal age.
Who could benefit from this research
Good fit: Ideal candidates for this research include women of reproductive age who are experiencing fertility issues or are concerned about the effects of aging on their reproductive health.
Not a fit: Patients who are not of reproductive age or those who do not have concerns related to fertility or ovarian health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for women facing infertility and pregnancy complications due to advanced maternal age.
How similar studies have performed: Previous research has shown promising results in understanding the roles of noncoding RNAs in reproductive health, suggesting that this approach could yield valuable insights.
Where this research is happening
BURLINGTON, UNITED STATES
- UNIVERSITY OF VERMONT & ST AGRIC COLLEGE — BURLINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KALLEN, AMANDA NICOLE — UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- Study coordinator: KALLEN, AMANDA NICOLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.