Understanding how certain genes affect male fertility in fruit flies
Essential roles for RNAi/hpRNAs to resolve intragenomic conflicts in the male germline
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11084472
This study looks at how certain genetic factors can affect reproduction in male fruit flies, which might help us understand issues like male infertility or imbalanced sex ratios in their babies, and the findings could eventually help people with reproductive health concerns.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11084472 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific genetic elements that can disrupt normal reproductive processes in male fruit flies. By studying how these elements interact with the genome, the research aims to uncover mechanisms that could lead to male sterility or skewed sex ratios in offspring. The approach involves advanced techniques like ATAC sequencing to analyze chromatin accessibility and gene expression. Patients may benefit from insights gained that could inform reproductive health and genetic counseling.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit would include individuals with concerns about genetic factors influencing fertility or reproductive health.
Not a fit: Patients who are not affected by genetic fertility issues or those not interested in reproductive health may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing genetic factors that affect male fertility.
How similar studies have performed: Other research has shown success in understanding genetic influences on fertility, making this approach promising but still exploring novel aspects.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAI, ERIC C — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: LAI, ERIC C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.