Understanding how certain genes affect kidney disease in children with HIV
Novel mechanisms and Drosophila model of APOL1-HIV-1 nephropathies in children
This study is looking at how certain genes, especially the APOL1 gene, might affect kidney health in kids with HIV by using fruit flies to see how these genes interact with the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10439649 on NIH RePORTER |
What this research studies
This research investigates the role of specific genetic factors, particularly the APOL1 gene, in the development of kidney disease among children infected with HIV. By using a Drosophila model, researchers aim to explore how these genetic variations interact with HIV to influence kidney health. The study involves creating genetically modified fruit flies to mimic human kidney cells and observing how they respond to HIV infection. This approach allows for a deeper understanding of the mechanisms behind HIV-related kidney disease in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children who are HIV-positive and carry the APOL1 risk alleles.
Not a fit: Patients who do not have HIV or do not carry the APOL1 risk alleles may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for kidney disease in children with HIV.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors in kidney disease, but this specific approach using Drosophila models is relatively novel.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Ray, Patricio E. — University of Virginia
- Study coordinator: Ray, Patricio E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.