Understanding how certain genes affect insulin-producing cells in diabetes
Investigating the functional roles of CTSH and PGM1 in beta-cells during autoimmune diabetes development
['FUNDING_CAREER'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11013416
This study is looking at how certain genes affect the insulin-producing cells in the pancreas, with the hope of finding better treatments for young kids with type 1 diabetes.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11013416 on ClinicalTrials.gov |
What this research studies
This research investigates the roles of specific genes, CTSH and PGM1, in the function of pancreatic beta-cells, which are crucial for insulin production. By using advanced models and technologies, the research aims to uncover how genetic and environmental factors contribute to the development of type 1 diabetes (T1D). The goal is to identify pathways that could lead to improved treatments for T1D, particularly for young children affected by this condition. The project is led by Dr. Jody Ye-Miller at the Albert Einstein College of Medicine, a prominent institution in medical research.
Who could benefit from this research
Good fit: Ideal candidates for this research are young children diagnosed with type 1 diabetes or those at risk of developing the condition.
Not a fit: Patients with type 2 diabetes or other forms of diabetes unrelated to autoimmune mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance beta-cell function and improve outcomes for patients with type 1 diabetes.
How similar studies have performed: Previous research has shown promise in understanding genetic influences on diabetes, making this approach both relevant and potentially impactful.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YE, JODY — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: YE, JODY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diabetes