Understanding how certain genes affect HIV persistence in people who use cocaine
Official title: Investigate Host Gene Isoforms Contributing to HIV Persistence in Cocaine Users
Funded at Ohio State University · NIH-10931677 · Data updated 2026-11-12
This study is looking at how certain genes might affect HIV in people who use cocaine, with the hope of finding new ways to help them manage their infection better and improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 30, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $715,222 |
| NIH project number | 5R01DA059538-02 |
| Project ID | NIH-10931677 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are HIV-infected individuals who also use cocaine and are struggling with persistent infection despite antiretroviral therapy.
✕Less likely to help
Patients who are HIV-negative or those who do not use cocaine may not receive any benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to the persistence of HIV infection in individuals who use cocaine. It aims to understand how host gene isoforms influence HIV replication and resistance, particularly in drug users, who face unique challenges in managing their HIV. By analyzing RNA sequencing data from various groups, including elite controllers who can control HIV without treatment, the study seeks to identify specific gene expressions that could lead to new treatment strategies. The ultimate goal is to find ways to eliminate residual HIV in patients, improving their health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for eradicating HIV in patients, particularly those who are drug users.
How similar studies have gone: Previous research has shown promise in understanding HIV persistence through genetic factors, but this specific approach focusing on cocaine users is relatively novel.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Zhu, Jian — Ohio State University
- Study coordinator: Zhu, Jian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.