Understanding how certain genes affect heart valve development and disease
Official title: Novel lymphatic genes that regulate heart valve development and disease
Funded at Oklahoma Medical Research Foundation · NIH-10983329 · Data updated 2026-11-12
This study is looking at how certain genes affect heart valves and lymphatic vessels, especially to help older adults who might have problems like lymphedema or heart valve issues, with the goal of finding ways to keep these valves healthy and working well.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $480,910 |
| NIH project number | 5R01HL163095-03 |
| Project ID | NIH-10983329 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who may be experiencing heart valve issues or related vascular conditions.
✕Less likely to help
Patients under the age of 65 or those without any heart valve or lymphatic vessel conditions may not benefit from this research.
What this research studies
This research investigates the role of specific genes in the development and function of heart valves and lymphatic vessels. It focuses on how defects in these valves can lead to serious conditions like lymphedema and degenerative heart valve disease, particularly in older adults. The researchers will explore a signaling pathway involving the PROX1 gene and its impact on the cells that make up these valves. By understanding these mechanisms, the study aims to identify potential targets for improving valve health and function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart valve diseases and related conditions, improving health outcomes for older patients.
How similar studies have gone: Other research has shown promise in understanding genetic factors in heart valve diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Srinivasan, Rajanarayanan S — Oklahoma Medical Research Foundation
- Study coordinator: Srinivasan, Rajanarayanan S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.