Understanding how certain genes affect fertility and health
Official title: Molecular Mechanisms and Evolutionary Impacts of the wtf Meiotic Drivers
Funded at Stowers Institute for Medical Research · NIH-11005322 · Data updated 2026-11-12
This study looks at certain genes that can affect how cells make sperm and eggs, which might lead to fertility problems, and by understanding these genes better, we hope to help people learn more about the genetic factors that could be impacting their reproductive health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stowers Institute for Medical Research NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $427,679 |
| NIH project number | 5R35GM151982-02 |
| Project ID | NIH-11005322 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing infertility or difficulties conceiving, potentially linked to genetic factors.
✕Less likely to help
Patients with infertility not related to genetic factors or those who have already achieved successful pregnancies may not benefit from this research.
What this research studies
This research investigates the role of meiotic drive genes, which are genetic elements that can manipulate the process of gametogenesis, potentially leading to infertility or health issues. By studying the wtf gene family in fission yeasts, the research aims to uncover the molecular mechanisms behind these genetic parasites and their evolutionary consequences. The findings could provide insights into how these genes disrupt normal chromosome segregation and contribute to fertility challenges. Patients may benefit from a better understanding of the genetic factors influencing their reproductive health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing infertility and improving reproductive health.
How similar studies have gone: While the specific focus on meiotic drivers is relatively novel, similar genetic research has shown promise in understanding fertility issues and genetic disorders.
Where this research is happening
-
Stowers Institute for Medical Research
Kansas City, United States Active
Researchers
- Principal investigator: Zanders, Sarah Elizabeth — Stowers Institute for Medical Research
- Study coordinator: Zanders, Sarah Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.