Understanding how certain genes affect cancer spread in head and neck cancer
Deciphering epigenetically-regulated pathways to improve targeted therapy for invasion and metastasis in head and neck cancer
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10993660
This study is looking at how a specific type of cancer in the head and neck spreads, and it's trying to find new ways to stop it by testing a special treatment that could help improve care for patients with this cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10993660 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the spread of head and neck squamous cell carcinoma (HNSCC), a type of cancer that often leads to high mortality rates. By analyzing unique cell states within tumors, particularly those that are neither fully epithelial nor mesenchymal, the researchers aim to identify key pathways that drive cancer invasion and metastasis. They are focusing on super-enhancers, which are crucial for maintaining cell identity, and testing a specific inhibitor to see if it can effectively reduce cancer spread. The goal is to find more targeted therapies that can improve treatment outcomes for patients with HNSCC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with head and neck squamous cell carcinoma, particularly those experiencing metastasis.
Not a fit: Patients with early-stage head and neck cancer who have not yet experienced metastasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective targeted therapies for patients with head and neck cancer, potentially improving survival rates.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in other cancers, suggesting that this approach may yield beneficial results.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PURAM, SIDHARTH VENKATA — WASHINGTON UNIVERSITY
- Study coordinator: PURAM, SIDHARTH VENKATA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Cause, Cancer Etiology