Understanding how certain genes affect cancer spread in head and neck cancer

Who could benefit from this research

What this research studies

This research investigates the mechanisms behind the spread of head and neck squamous cell carcinoma (HNSCC), a type of cancer that often leads to high mortality rates. By analyzing unique cell states within tumors, particularly those that are neither fully epithelial nor mesenchymal, the researchers aim to identify key pathways that drive cancer invasion and metastasis. They are focusing on super-enhancers, which are crucial for maintaining cell identity, and testing a specific inhibitor to see if it can effectively reduce cancer spread. The goal is to find more targeted therapies that can improve treatment outcomes for patients with HNSCC.

Why it matters

Where this research is happening

• Washington University
  Saint Louis, United States Active

Researchers

• Principal investigator: Puram, Sidharth Venkata — Washington University
• Study coordinator: Puram, Sidharth Venkata

Related research

Other NIH-funded projects on the same topics.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.