Understanding how certain genes affect brain development in children with neurodevelopmental disorders
The Role of Fos and the BAF Complex in Neuronal Activity-Dependent Chromatin Remodeling and Gene Expression
['FUNDING_CAREER'] · BOSTON CHILDREN'S HOSPITAL · NIH-11064767
This study is looking at how certain genes affect brain development and function in kids with conditions like autism and epilepsy, focusing on a protein called Fos, to find new ways to help treat these disorders.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11064767 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic mechanisms that influence brain development and function in children with neurodevelopmental disorders such as autism and epilepsy. It focuses on the role of a protein called Fos and its interaction with a chromatin remodeling complex, which may be crucial for regulating gene expression in response to neuronal activity. By studying how these genetic programs are activated and how variations in these genes affect brain function, the research aims to uncover new therapeutic targets for treating these disorders. The approach includes analyzing cell-type-specific binding sites and their impact on neurodevelopment.
Who could benefit from this research
Good fit: Ideal candidates for this research include children diagnosed with neurodevelopmental disorders such as autism spectrum disorder, pediatric epilepsy, or intellectual disabilities.
Not a fit: Patients with neurodevelopmental disorders not related to the genetic mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies for pediatric neurodevelopmental disorders, improving outcomes for affected children.
How similar studies have performed: While the specific interactions being studied are novel, previous research has shown success in understanding genetic factors in neurodevelopmental disorders, indicating potential for impactful findings.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TROWBRIDGE, SARA — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: TROWBRIDGE, SARA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder, autism spectrum disorder, Autistic Disorder, autistic spectrum disorder