Understanding how certain genes affect brain degeneration in Alzheimer's Disease.
Elucidation of the mechanisms by which Ms4a genes regulate neurodegeneration in Alzheimer’s Disease and related disorders
['FUNDING_OTHER'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11170844
This study is looking at how certain genes, called Ms4a genes, might help improve thinking and behavior in people with Alzheimer's and other brain disorders, with the hope of finding new treatments that could help patients feel better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11170844 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Ms4a genes in neurodegenerative disorders, particularly Alzheimer's Disease. The team has discovered that deleting the Ms4a6c gene in mouse models leads to improvements in cognitive and behavioral functions. By exploring the genetic links between Ms4a genes and conditions like Alzheimer's, frontotemporal dementia, and others, the research aims to develop new therapeutic strategies that could benefit patients suffering from these diseases. The approach combines genetic analysis with behavioral assessments in animal models to uncover potential treatment pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's Disease or related dementias, particularly those with a family history of these conditions.
Not a fit: Patients with neurodegenerative disorders not linked to Ms4a gene polymorphisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the treatment of Alzheimer's Disease and related neurodegenerative disorders.
How similar studies have performed: Previous research has shown promising results in targeting genetic factors related to neurodegeneration, suggesting that this approach could yield significant advancements.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GREER, PAUL LIEBERMAN — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: GREER, PAUL LIEBERMAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease and related dementia, Alzheimer's disease and related disorders