Understanding how certain genes affect antifungal drug effectiveness and fungal infections
SET Domain Epigenetic Factors Govern Antifungal Drug Efficacy and Fungal Pathogenesis
This study is looking at how certain genetic factors affect how well antifungal drugs work, especially for people with weakened immune systems, like those with HIV, cancer, or diabetes, to help find better treatments for tough fungal infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-10462528 on NIH RePORTER |
What this research studies
This research investigates the role of SET domain epigenetic factors in influencing the effectiveness of antifungal drugs and the development of fungal infections. It focuses on understanding how these genetic factors contribute to drug resistance, particularly in patients who are immunocompromised, such as those with HIV, cancer, or diabetes. By using model organisms like yeast and larvae, the study aims to identify new molecular targets for antifungal drug development, potentially leading to more effective treatments for resistant fungal infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who are immunocompromised and at high risk for fungal infections, including those with HIV, undergoing cancer treatment, or with advanced diabetes.
Not a fit: Patients with non-fungal infections or those who are not immunocompromised may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antifungal drugs that are more effective against resistant fungal infections, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding drug resistance mechanisms in fungi, indicating that this approach could yield valuable insights and advancements.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Briggs, Scott D — Purdue University
- Study coordinator: Briggs, Scott D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.