Understanding how certain genes affect allergic diseases like asthma.
Regulation of FcεRI function by the MS4A gene cluster
['FUNDING_R01'] · NORTH CAROLINA STATE UNIVERSITY RALEIGH · NIH-10683212
This study is looking at how certain genes affect the immune system in people with allergies like asthma and eczema, hoping to find new ways to create better treatments that are personalized for each patient.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA STATE UNIVERSITY RALEIGH (nih funded) |
| Locations | 1 site (RALEIGH, UNITED STATES) |
| Trial ID | NIH-10683212 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the MS4A gene cluster in regulating immune responses related to allergic diseases such as asthma and atopic dermatitis. By examining how these genes influence mast cell behavior, the study aims to identify new therapeutic targets that could lead to more effective treatments. The approach includes genetic analysis and exploration of environmental factors that may contribute to allergic conditions. Patients may benefit from insights that could lead to novel therapies tailored to their specific genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from allergic diseases like asthma or atopic dermatitis, particularly those with a family history of these conditions.
Not a fit: Patients with non-allergic conditions or those who do not have a genetic predisposition to allergic diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively manage allergic diseases and improve patient quality of life.
How similar studies have performed: Previous research has shown promising results in targeting genetic factors related to allergic diseases, indicating that this approach has potential for success.
Where this research is happening
RALEIGH, UNITED STATES
- NORTH CAROLINA STATE UNIVERSITY RALEIGH — RALEIGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CRUSE, GLENN PAUL — NORTH CAROLINA STATE UNIVERSITY RALEIGH
- Study coordinator: CRUSE, GLENN PAUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome