Understanding how certain gene variants affect heart muscle conditions.
Official title: Mechanisms linking the frail sarcomere to noncompaction cardiomyopathy
Funded at Northwestern University at Chicago · NIH-10896446 · Data updated 2026-11-12
This study is looking at how certain gene changes in the MYH7 gene might affect heart function in people with a heart condition called left ventricular noncompaction cardiomyopathy (LVNC), and it aims to help improve diagnosis and treatment for those who have it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $108,935 |
| NIH project number | 5K99HL168239-02 |
| Project ID | NIH-10896446 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with diagnosed left ventricular noncompaction cardiomyopathy or those with family histories of related cardiac conditions.
✕Less likely to help
Patients without any genetic predisposition to cardiomyopathies or those with unrelated heart conditions may not benefit from this research.
What this research studies
This research investigates the role of specific gene variants in the MYH7 gene, which are linked to a heart condition known as left ventricular noncompaction cardiomyopathy (LVNC). Using advanced techniques, the researchers will create heart muscle cells from human stem cells that carry these gene variants to study their effects on heart function. By examining how these variants influence heart muscle cell behavior, the research aims to uncover mechanisms that lead to LVNC, potentially improving diagnosis and treatment options for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of heart conditions related to MYH7 gene variants.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors in cardiomyopathies, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Monroe, Tanner O — Northwestern University at Chicago
- Study coordinator: Monroe, Tanner O
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.