Understanding how certain fungi survive and cause infections in humans
Official title: Genetics of fungal persistence and pathogenicity in mammalian hosts
Funded at University of Southern California · NIH-10874018 · Data updated 2026-11-12
This study is looking at how certain fungi, like yeast, can cause infections in people, and it aims to find out what makes them so good at it, which could help create better treatments for those dealing with fungal infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | August 17, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $623,986 |
| NIH project number | 1R56AI171091-01A1 |
| Project ID | NIH-10874018 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of opportunistic fungal infections, such as those with weakened immune systems or underlying health conditions.
✕Less likely to help
Patients who do not have a history of fungal infections or are not at risk for such infections may not benefit from this research.
What this research studies
This research investigates the genetic and molecular factors that allow certain fungi, particularly Saccharomyces cerevisiae, to persist and cause infections in human hosts. By using advanced genetic techniques, the researchers aim to identify specific genes and mechanisms that contribute to the pathogenicity of these fungi. The study involves tracking the growth and behavior of genetically modified yeast strains in mouse models to uncover how these organisms interact with mammalian systems. This knowledge could lead to the development of more effective antifungal treatments for patients suffering from opportunistic fungal infections.
Why it matters
Potential benefit: If successful, this research could lead to improved antifungal therapies, enhancing treatment options for patients with serious fungal infections.
How similar studies have gone: Previous research has shown promise in understanding fungal genetics and pathogenicity, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Ehrenreich, Ian Michael — University of Southern California
- Study coordinator: Ehrenreich, Ian Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.