Understanding how certain fungi develop drug resistance
RNAi-dependent epimutation roles in antimicrobial drug resistance and pathogenesis
This study is looking at a group of tough fungi that can cause serious infections and are hard to treat, to understand how they become resistant to medications, with the hope of finding better ways to help patients recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10883738 on NIH RePORTER |
What this research studies
This research investigates the Mucor species complex, a group of fungi that cause severe infections and are challenging to treat due to limited drug options. The study focuses on how these fungi can develop resistance to antifungal drugs through a process called epimutation, which involves the activation of RNA interference pathways. By using advanced genetic and molecular techniques, the researchers aim to uncover the mechanisms behind this resistance and how it can be reversed, potentially leading to more effective treatments for patients with these infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from severe infections caused by Mucor fungi, particularly those who have limited treatment options.
Not a fit: Patients with infections caused by other types of fungi or those who do not have severe infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating difficult fungal infections, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding drug resistance mechanisms in fungi, suggesting that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Heitman, Joseph — Duke University
- Study coordinator: Heitman, Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.