Understanding how certain fungi cause disease
CRISPR and Virulence Core
This study is looking at how the fungi that cause Valley fever work and uses a special technique to change their genes, which could help us find better ways to treat infections and improve care for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11004126 on NIH RePORTER |
What this research studies
This research investigates the virulence mechanisms of the fungi Coccidioides immitis and C. posadasii, which are responsible for Valley fever. By using CRISPR technology, the team aims to delete specific genes in these fungi to observe changes in their ability to cause disease. This approach will help identify the genetic factors that contribute to their pathogenicity and could lead to better treatment strategies. Patients may benefit from improved understanding and potential new therapies for fungal infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with coccidioidomycosis or are at high risk for developing this infection.
Not a fit: Patients with fungal infections not caused by Coccidioides species may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Valley fever and other fungal infections.
How similar studies have performed: Previous research using CRISPR technology to investigate fungal pathogens has shown promise, indicating that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Barker, Bridget Marie — University of California, San Francisco
- Study coordinator: Barker, Bridget Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.