Understanding how certain fungi become harmful to humans
Deciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relatives
['FUNDING_R01'] · VANDERBILT UNIVERSITY · NIH-10994599
This study is looking at how certain types of fungi, like Aspergillus fumigatus, can make people sick, and it’s for anyone interested in understanding how these fungi evolve and what makes them harmful, which could help improve ways to prevent and treat infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-10994599 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic and phenotypic traits that allow the fungus Aspergillus fumigatus and its relatives to cause disease in humans. By examining the differences between pathogenic and non-pathogenic species, the study aims to uncover the evolutionary processes that lead to pathogenicity. The approach includes analyzing the genetic makeup and growth characteristics of these fungi, particularly their ability to thrive at human body temperature and produce harmful substances. This research could provide insights into how these fungi evolve and adapt, potentially leading to better prevention and treatment strategies for infections.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals at high risk for Aspergillus infections, such as those with weakened immune systems or chronic lung diseases.
Not a fit: Patients who do not have any risk factors for fungal infections or those who are not affected by Aspergillus species may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of fungal infections, ultimately reducing morbidity and mortality associated with Aspergillus-related diseases.
How similar studies have performed: Previous research has shown success in understanding the genetic basis of pathogenicity in other fungal species, suggesting that this approach may yield valuable insights.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROKAS, ANTONIS — VANDERBILT UNIVERSITY
- Study coordinator: ROKAS, ANTONIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.