Understanding how certain fish survive extreme conditions to help combat aging
Decoding natural protective mechanisms during diapause and longevity to counter aging
This study is looking at how the African turquoise killifish can pause its aging process to survive tough conditions, and by learning from these fish, researchers hope to find new ways to help people live healthier and longer, especially those dealing with age-related issues like Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10687588 on NIH RePORTER |
What this research studies
This research investigates the unique survival adaptations of the African turquoise killifish, which can enter a state of suspended animation to survive harsh environments. By studying these extremophiles, researchers aim to uncover novel genes and mechanisms that could help slow aging and improve health outcomes in humans. The project focuses on understanding how these fish manage to pause their aging process during diapause, potentially offering insights into longevity and age-related diseases. Patients may benefit from findings that could lead to new treatments for conditions like Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21, particularly those at risk for or suffering from age-related conditions such as Alzheimer's disease.
Not a fit: Patients with acute or non-age-related conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in therapies that slow aging and improve health in older adults.
How similar studies have performed: While the approach of studying extremophiles for aging research is relatively novel, similar studies have shown promise in understanding longevity mechanisms in other species.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Singh, Param Priya — University of California, San Francisco
- Study coordinator: Singh, Param Priya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.