Understanding how certain fatty acids affect heart injury and inflammation
Bridging the gap of endogenous nitro-conjugated linoleic acid formation and signaling
This study is looking at how a special fatty acid called nitro-conjugated linoleic acid is made in the heart during times when blood flow is cut off, and it hopes to find new ways to help treat heart injuries and inflammation that could benefit patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11115548 on NIH RePORTER |
What this research studies
This research investigates the formation and signaling of nitro-conjugated linoleic acid (NO2-CLA) during heart injuries caused by interrupted blood flow. It focuses on how this fatty acid, which has anti-inflammatory properties, is produced in the heart and its potential role in modulating cellular signaling pathways. By studying the mechanisms of lipid nitration and its effects on heart cells, the research aims to uncover new insights into treating heart-related conditions. Patients may benefit from findings that could lead to novel therapeutic strategies for heart injury and inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of cardiac ischemia or those at risk for heart-related injuries.
Not a fit: Patients with non-cardiac related conditions or those not experiencing ischemic events may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce heart damage and inflammation during cardiac events.
How similar studies have performed: Previous research has shown promising results in understanding lipid nitration and its effects, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Colussi, Nicole — University of Pittsburgh at Pittsburgh
- Study coordinator: Colussi, Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.