Understanding how certain fatty acids affect heart injury and inflammation
Official title: Bridging the gap of endogenous nitro-conjugated linoleic acid formation and signaling
Funded at University of Pittsburgh at Pittsburgh · NIH-11115548 · Data updated 2026-11-12
This study is looking at how a special fatty acid called nitro-conjugated linoleic acid is made in the heart during times when blood flow is cut off, and it hopes to find new ways to help treat heart injuries and inflammation that could benefit patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | June 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $40,100 |
| NIH project number | 5F31HL172595-02 |
| Project ID | NIH-11115548 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of cardiac ischemia or those at risk for heart-related injuries.
✕Less likely to help
Patients with non-cardiac related conditions or those not experiencing ischemic events may not benefit from this research.
What this research studies
This research investigates the formation and signaling of nitro-conjugated linoleic acid (NO2-CLA) during heart injuries caused by interrupted blood flow. It focuses on how this fatty acid, which has anti-inflammatory properties, is produced in the heart and its potential role in modulating cellular signaling pathways. By studying the mechanisms of lipid nitration and its effects on heart cells, the research aims to uncover new insights into treating heart-related conditions. Patients may benefit from findings that could lead to novel therapeutic strategies for heart injury and inflammation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce heart damage and inflammation during cardiac events.
How similar studies have gone: Previous research has shown promising results in understanding lipid nitration and its effects, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Colussi, Nicole — University of Pittsburgh at Pittsburgh
- Study coordinator: Colussi, Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.