Understanding how certain fats in our cells affect DNA damage and cancer
Neutral Sphingomyelinases and Bioactive Ceramides
['FUNDING_OTHER'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-11123885
This research explores how specific fats within our cells, called ceramides, play a role in how our bodies respond to DNA damage, which is important for understanding cancers.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-11123885 on ClinicalTrials.gov |
What this research studies
Our cells contain special fats called sphingolipids, including ceramides, which act like messengers. This project aims to uncover the exact ways these fats are made and how they work inside cells, especially when DNA gets damaged. We want to understand how specific enzymes create these ceramides in different parts of the cell and how these fats then trigger important cell responses. By focusing on these detailed mechanisms, we hope to gain a clearer picture of their role in cellular stress and diseases like cancer.
Who could benefit from this research
Good fit: Patients with cancers or conditions involving DNA injury might eventually benefit from treatments developed based on this fundamental understanding.
Not a fit: Patients seeking immediate new treatments would not directly benefit from this foundational laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to target specific cellular pathways involved in DNA damage and cancer development.
How similar studies have performed: This research builds upon strong existing data and aims to define totally unexpected roles for these cellular components, suggesting a blend of established and novel approaches.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HANNUN, YUSUF AWNI — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: HANNUN, YUSUF AWNI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, DNA Injury