Understanding how certain fats can cause cell damage and inflammation
Official title: Pathways of peroxidation: defining the autoxidation of polyunsaturated fatty acids and the cellular consequences
Funded at Louisiana State Univ A&m Col Baton Rouge · NIH-10937204 · Data updated 2026-11-12
This study is looking at how certain healthy fats in our bodies can change and cause problems, like inflammation and chronic diseases, and it hopes to find new ways to help people who are dealing with these health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ A&m Col Baton Rouge NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $369,174 |
| NIH project number | 1R35GM154857-01 |
| Project ID | NIH-10937204 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic diseases such as cancers, cardiovascular diseases, diabetes, or neurodegenerative disorders.
✕Less likely to help
Patients with acute inflammatory conditions that do not involve chronic disease processes may not benefit from this research.
What this research studies
This research investigates the process of autoxidation of polyunsaturated fatty acids (PUFAs) and how this leads to harmful cellular changes. By examining the role of these fats in inflammation and chronic diseases, the study aims to identify the mechanisms by which toxic products form and affect cell function. The research employs advanced biochemical techniques to map the pathways of these fatty acids and their byproducts, focusing on their impact on mitochondrial proteins. Patients may benefit from insights gained that could lead to new treatments for conditions linked to chronic inflammation.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing chronic diseases associated with inflammation.
How similar studies have gone: Previous research has shown that targeting oxidative stress and inflammation can lead to significant improvements in chronic disease management, indicating a promising avenue for this study.
Where this research is happening
-
Louisiana State Univ A&m Col Baton Rouge
Baton Rouge, United States Active
Researchers
- Principal investigator: Beavers, William Norris — Louisiana State Univ A&m Col Baton Rouge
- Study coordinator: Beavers, William Norris
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.