Understanding how certain fats and signaling molecules work in the cell nucleus.
Official title: Structure and function of phospholipids and inositol phosphates in the nucleus.
Funded at Vanderbilt University Medical Center · NIH-11011411 · Data updated 2026-11-12
This study is looking at how certain tiny molecules in our cells might work in the nucleus, which is the control center of the cell, to help us understand their roles better and find new ways to treat different diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | May 5, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $778,444 |
| NIH project number | 1R35GM156389-01 |
| Project ID | NIH-11011411 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions influenced by cellular signaling, such as certain cancers or metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to cellular signaling or those who do not have access to the research facilities may not benefit from this research.
What this research studies
This research investigates the roles of phospholipids and inositol phosphates, which are small molecules known for their functions in the cytoplasm, but whose roles in the nucleus are not well understood. The team aims to explore the structural biology and functional genomics of these molecules, using innovative chemical biology techniques to develop new small molecules that can help uncover their nuclear functions. By studying how these molecules interact with nuclear receptors, the research seeks to inform the development of new therapies for various human diseases. This work could lead to a better understanding of cellular signaling and metabolism, potentially impacting treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to cellular signaling and metabolism.
How similar studies have gone: Previous research has shown promise in understanding cellular signaling through similar approaches, indicating potential for success in this area.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Blind, Raymond Daniel — Vanderbilt University Medical Center
- Study coordinator: Blind, Raymond Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.