Understanding how certain fats affect ion channel function
Official title: Unraveling how Lipophilic Modulators Alter pLGIC Function via Interactions with the M4 Transmembrane Helix
Funded at Washington University · NIH-10916479 · Data updated 2026-11-12
This study is looking at how certain fat-soluble substances affect specific ion channels in the body, which could help us understand how to create better treatments for conditions related to these channels, like those affecting anesthesia.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $185,953 |
| NIH project number | 5K08GM152844-02 |
| Project ID | NIH-10916479 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing procedures requiring anesthesia or those with conditions related to ion channel abnormalities.
✕Less likely to help
Patients with conditions unrelated to ion channel function or those not requiring anesthesia may not benefit from this research.
What this research studies
This research investigates how lipophilic modulators, which are fat-soluble substances, influence the function of specific ion channels in the body. The study focuses on pentameric ligand-gated ion channels (pLGICs) and aims to uncover the molecular mechanisms by which these modulators interact with the channels. Using advanced computational techniques, the research will analyze the structural changes in these channels under different functional states, which could lead to better drug design targeting these channels. Patients may benefit from insights gained about anesthetic actions and potential new treatments for conditions related to ion channel dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective anesthetics and treatments for conditions involving ion channel dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding the role of lipids in ion channel function, indicating that this approach has potential for success.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Arcario, Mark Joseph — Washington University
- Study coordinator: Arcario, Mark Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.