Understanding how certain fats affect inflammation caused by oral bacteria
Official title: Defining the role of sphingolipids on Porphyromonas gingivalis outer membrane vesicle uptake and elicited inflammation
Funded at University of Florida · NIH-10895305 · Data updated 2026-11-12
This study is looking at how certain fats in the body affect the way a specific bacteria linked to gum disease causes inflammation, with the hope of finding better ways to prevent and treat periodontal disease for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | August 16, 2023 |
| Project end | August 15, 2025 |
| Funding year | 2024 |
| Award (this year) | $46,103 |
| NIH project number | 5F31DE033255-02 |
| Project ID | NIH-10895305 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over the age of 30 who are experiencing or are at risk for periodontal disease.
✕Less likely to help
Patients who do not have periodontal disease or are under 30 years old may not receive benefit from this research.
What this research studies
This research investigates the role of sphingolipids, a type of fat, in how the bacteria Porphyromonas gingivalis interacts with the body and causes inflammation. The study aims to understand the mechanisms behind this interaction, which could lead to better prevention and treatment strategies for periodontal disease. By examining how these fats influence the uptake of bacterial outer membrane vesicles, the research seeks to uncover new insights into chronic inflammation related to oral health. Patients may benefit from improved understanding and management of periodontal disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating periodontal disease, potentially improving oral health for many patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of oral bacteria in periodontal disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Eure, Zavier G — University of Florida
- Study coordinator: Eure, Zavier G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.