Understanding how certain fats affect a type of cell death called ferroptosis
Ferroptosis and Polyunsaturated Fatty Acid Metabolism
This study is looking at how certain fatty acids in our body can affect a special type of cell death that’s linked to iron and fat damage, using tiny worms to learn more about how these fatty acids might help us understand and treat health issues related to aging and tissue health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11082533 on NIH RePORTER |
What this research studies
This research investigates the role of oxidized polyunsaturated fatty acids (PUFAs) in regulating ferroptosis, a unique form of cell death that is influenced by iron and characterized by lipid damage. The team is developing chemical tools and using a model organism, C. elegans, to explore how these fatty acids impact health and disease. By synthesizing specific PUFA metabolites, they aim to uncover new biological effects and mechanisms that could lead to better understanding and treatment of various conditions related to cell aging and tissue health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in conditions related to cellular aging or diseases influenced by cell death mechanisms.
Not a fit: Patients with conditions unrelated to cellular metabolism or those not affected by ferroptosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for diseases linked to cell death and aging.
How similar studies have performed: While the specific approach of investigating PUFA metabolites in ferroptosis is relatively novel, similar studies have shown promise in understanding cell death mechanisms.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Lee, Kin Sing Stephen — Michigan State University
- Study coordinator: Lee, Kin Sing Stephen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.