Understanding how certain factors influence the ability of specific brain cells to regenerate
Intrinsic and Extrinsic factors regulating neurogenic competence in hypothalamic tanycytes
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-10929516
This study is looking at how certain brain cells can grow new neurons and what helps them do that, which could lead to better treatments for metabolic disorders that affect people like you.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10929516 on ClinicalTrials.gov |
What this research studies
This research investigates the factors that affect the ability of hypothalamic tanycytes, a type of brain cell, to regenerate and produce new neurons. The study will explore the role of a specific transcription factor, Ascl1, and a signaling pathway known as Shh in promoting the survival of neurons derived from these cells. By using advanced genetic techniques and zebrafish models, the research aims to uncover the mechanisms that regulate neurogenic competence, which could lead to new treatments for metabolic disorders. Patients may benefit from insights gained about how to enhance neuronal regeneration in the hypothalamus.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with metabolic disorders or conditions related to hypothalamic function.
Not a fit: Patients with conditions unrelated to hypothalamic function or those who are not affected by metabolic disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating metabolic and homeostatic disorders by enhancing the regeneration of specific brain cells.
How similar studies have performed: Other research has shown promising results in understanding neurogenic competence in various cell types, suggesting that this approach may yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUNCAN, LEIGHTON HOSEA — JOHNS HOPKINS UNIVERSITY
- Study coordinator: DUNCAN, LEIGHTON HOSEA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus