Understanding how certain factors affect respiratory syncytial virus infection
Official title: Role of Hypoxia-Inducible Factors (HIFs) in Respiratory Syncytial Virus Infection
Funded at University of Texas Med Br Galveston · NIH-10868643 · Data updated 2026-11-12
This study is looking at how certain factors in our bodies can affect the severity of respiratory syncytial virus (RSV) infections, which mainly impact infants and older adults, to find new ways to help improve treatment for those who get sick.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | June 16, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $200,000 |
| NIH project number | 5R21AI175955-02 |
| Project ID | NIH-10868643 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include infants and older adults who are at high risk for severe RSV infections.
✕Less likely to help
Patients with RSV infections who do not fall into the high-risk categories, such as healthy adults, may not receive significant benefits from this research.
What this research studies
This research investigates the role of hypoxia-inducible factors (HIFs) in the infection process of respiratory syncytial virus (RSV), which is a significant cause of respiratory illness in infants and older adults. The study aims to explore how manipulating HIF levels can influence the severity of RSV infections. By using animal models, researchers will assess the effects of HIF inhibitors and stabilizers on viral replication and disease outcomes. The goal is to identify potential therapeutic strategies that could improve patient outcomes in those affected by RSV.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for respiratory syncytial virus infections, particularly in vulnerable populations such as infants and the elderly.
How similar studies have gone: While there has been success in using HIF inhibitors and stabilizers in other contexts, this specific application in viral infections is novel and has not been extensively tested.
Where this research is happening
-
University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Casola, Antonella — University of Texas Med Br Galveston
- Study coordinator: Casola, Antonella
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.