Understanding how certain factors affect respiratory syncytial virus infection
Role of Hypoxia-Inducible Factors (HIFs) in Respiratory Syncytial Virus Infection
['FUNDING_R21'] · UNIVERSITY OF TEXAS MED BR GALVESTON · NIH-10868643
This study is looking at how certain factors in our bodies can affect the severity of respiratory syncytial virus (RSV) infections, which mainly impact infants and older adults, to find new ways to help improve treatment for those who get sick.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS MED BR GALVESTON (nih funded) |
| Locations | 1 site (GALVESTON, UNITED STATES) |
| Trial ID | NIH-10868643 on ClinicalTrials.gov |
What this research studies
This research investigates the role of hypoxia-inducible factors (HIFs) in the infection process of respiratory syncytial virus (RSV), which is a significant cause of respiratory illness in infants and older adults. The study aims to explore how manipulating HIF levels can influence the severity of RSV infections. By using animal models, researchers will assess the effects of HIF inhibitors and stabilizers on viral replication and disease outcomes. The goal is to identify potential therapeutic strategies that could improve patient outcomes in those affected by RSV.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants and older adults who are at high risk for severe RSV infections.
Not a fit: Patients with RSV infections who do not fall into the high-risk categories, such as healthy adults, may not receive significant benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for respiratory syncytial virus infections, particularly in vulnerable populations such as infants and the elderly.
How similar studies have performed: While there has been success in using HIF inhibitors and stabilizers in other contexts, this specific application in viral infections is novel and has not been extensively tested.
Where this research is happening
GALVESTON, UNITED STATES
- UNIVERSITY OF TEXAS MED BR GALVESTON — GALVESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CASOLA, ANTONELLA — UNIVERSITY OF TEXAS MED BR GALVESTON
- Study coordinator: CASOLA, ANTONELLA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.